PRP vs Exosomes vs Polynucleotides: Choosing the Right Treatment

Article 10

As we explore advanced treatments for skin and hair health, patients often ask, “Which approach is best for me?” At Dr Adam Alluris Aesthetics, I’m introducing three highly effective treatments — PRP, Exosomes, and Polynucleotides — each with a distinct mechanism and role. Understanding these differences will help you make an informed choice about your treatment pathway.

PRP (Platelet‑Rich Plasma): The Autologous Option

PRP uses platelets and growth factors derived from your own blood. Its role is well established for skin revitalisation and hair restoration.

• 🌱 Source: Your own blood (autologous)
• 💉 Best for: Skin texture, scarring, early hair thinning
• ⚡️ How it works: Rich in growth factors that stimulate collagen and cellular renewal.
• ⏳ Duration: Results build over 4–6 weeks, lasting 12–18 months with maintenance.
• 📅 Treatment Course: Typically 3–4 treatments, spaced 4–6 weeks apart.
  👉 Learn more: PRP Treatments

Exosomes: The Precision Messengers

Exosomes are tiny, powerful cellular messengers that carry growth factors and cytokines. They can be sourced from:

• Human‑derived (e.g., mesenchymal stem cells): Highly potent and well‑researched.
• Plant‑derived (e.g., rose or barley exosomes): A natural option with a strong focus on anti‑inflammation and barrier support.
• Microorganism‑derived (e.g., probiotic strains): Gentle yet effective for skin barrier restoration.

Exosomes stimulate cellular renewal, making them ideal for fine lines, pigmentation, and general revitalisation.

• ⚡️ Duration: Results noticeable within 3–4 weeks.
• 📅 Treatment Course: 3–4 treatments, spaced every 3–4 weeks, with maintenance every 4–6 months.
  👉 Learn more: Exosomes in Aesthetic Medicine

Polynucleotides: The DNA Fragments Driving Healing

Polynucleotides are highly purified DNA fragments that stimulate fibroblasts, promoting collagen synthesis and tissue repair.

• 🌱 Best for: Under‑eye treatments, delicate or thin skin, and long‑term collagen support.
• ⚡️ Duration: Gradual improvements over 3–4 weeks, with noticeable effects peaking at 3–6 months.
• 📅 Treatment Course: 3–4 treatments spaced every 3–4 weeks, with maintenance every 6–12 months.
  👉 Learn more: Polynucleotide Treatments

The Choice‑Making Protocol: What’s Right for You?

Each patient is unique — and so is their ideal treatment. Here’s how I guide patients in making the right choice:

✅ If you want an autologous, ‘from‑you’ approach — PRP is ideal.
✅ If you want precision cellular messaging and enhanced recovery — Exosomes are worth considering.
✅ If your focus is long‑term structural improvement, especially for delicate areas — Polynucleotides may be best.

In Practice, At Dr Adam Alluris Aesthetics:
- I assess your skin condition and medical background.
- We consider your priorities — hydration, tightening, hair restoration, or overall rejuvenation.
- We review clinical evidence and match the treatment to your needs and expectations.

Each approach can also be combined strategically for maximum results. Together, we design a tailored plan that reflects both the latest advances in regenerative aesthetics and your personal goals.

Final Thoughts from Dr Adam

“As I often tell patients, choosing between PRP, Exosomes, and Polynucleotides is about aligning treatment benefits with your unique needs and aspirations. My role is to guide you, educate you, and craft a pathway that delivers results you can trust.”

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Stay Tuned for the last addition to Beneath the Surface Series to learn about Sculpting the face at the layer of deeper tissues with poly-L-lactic acid.