--- title: Medical Microneedling with Exosomes London | Dr Alluris Aesthetics description: Medical microneedling reaches depths a beauty therapist cannot. Dr Adam explains why depth and exosomes change what this treatment can actually achieve. image: https://www.drallurisaesthetics.co.uk/hubfs/Blog%20article%20banner%20(1).png --- [Skip to content](https://www.drallurisaesthetics.co.uk/journal/medical-microneedling-with-exosomes-london#main-content) [![Dr Alluris Aesthetics Logomark](https://www.drallurisaesthetics.co.uk/hs-fs/hubfs/Logomark%20-%20Golden-3.png?width=100&height=89&name=Logomark%20-%20Golden-3.png "Dr Alluris Aesthetics Logomark")](https://www.drallurisaesthetics.co.uk/) - [Home](https://www.drallurisaesthetics.co.uk) - [About](https://www.drallurisaesthetics.co.uk/about) - [Services](https://www.drallurisaesthetics.co.uk/services) - [Consultations](https://www.drallurisaesthetics.co.uk/services-consultations) - [Anti-Wrinkle Treatments](https://www.drallurisaesthetics.co.uk/services-anti-wrinkle-treatments) - [Sculpting Techniques (Face & Body)](https://www.drallurisaesthetics.co.uk/categories-sculpting-techniques) - [Dermal Fillers](https://www.drallurisaesthetics.co.uk/services-dermal-fillers) - [Fat-Dissolvers](https://www.drallurisaesthetics.co.uk/services-fat-dissolving-treatments) - [Regenerative Techniques / Skin Boosters](https://www.drallurisaesthetics.co.uk/categories-skin-boosters) - [Polynucleotides](https://www.drallurisaesthetics.co.uk/services-polynucleotides) - [PLLA](https://www.drallurisaesthetics.co.uk/services-plla) - [Microneedling](https://www.drallurisaesthetics.co.uk/services-microneedling-add-ons) - [Growth Factors](https://www.drallurisaesthetics.co.uk/services-microneedling-add-ons#addon-growth_factor_serums) - [Mesotherapies](https://www.drallurisaesthetics.co.uk/services-microneedling-add-ons#addon-mesotherapies) - [Exosomes](https://www.drallurisaesthetics.co.uk/services-microneedling-add-ons#addon-exosomes) - [Hair Restorative Treatments](https://www.drallurisaesthetics.co.uk/services-hair-restorative-treatments) - Smart Plans - [Bundles](https://www.drallurisaesthetics.co.uk/smart-plans-bundles) - [Packages](https://www.drallurisaesthetics.co.uk/smart-plans-packages) - [Gallery](https://www.drallurisaesthetics.co.uk/gallery) - [Journal](https://www.drallurisaesthetics.co.uk/journal) - [Contact Us](https://www.drallurisaesthetics.co.uk/contact-us) - [Book Your Consultation](https://partner.pabau.com/online-bookings/dr-alluris-aesthetics-ltd) - [Expert Insights](https://www.drallurisaesthetics.co.uk/journal/tag/expert-insights), - [Aesthetic Treatments](https://www.drallurisaesthetics.co.uk/journal/tag/aesthetic-treatments), - [Exosomes](https://www.drallurisaesthetics.co.uk/journal/tag/exosomes), - [Medical Microneedling](https://www.drallurisaesthetics.co.uk/journal/tag/medical-microneedling) # What Most Microneedling Treatments Are Missing ![Clinical illustration of a skin cross-section showing dermal layers with gold light beams penetrating to varying depths, representing medical microneedling treatment at Dr Alluris Aesthetics London](https://www.drallurisaesthetics.co.uk/hubfs/Blog%20article%20banner%20(1).png) - June 16, 2026 ![Dr Adam](https://www.drallurisaesthetics.co.uk/hubfs/Imported_Blog_Media/698b080f34f508925c96ea50_PXL_20250116_171922760-me-v3-cropped-1-1.png) [Dr Adam](https://www.drallurisaesthetics.co.uk/journal/author/dr-adam) ## **What Most Microneedling Treatments Are Missing** If you have had microneedling before and felt the results were underwhelming, there is usually a straightforward reason. What this treatment can achieve depends almost entirely on how deep the needles go and what is applied during the treatment. Both of those things are determined by who is performing it. ## **What you are actually noticing** Microneedling stimulates collagen by creating controlled micro-injuries in the dermis. The repair response that follows produces new collagen, improves texture, and over a course of sessions creates meaningful change in skin quality. The evidence for this is solid. The catch is that this response only begins once the needle reaches the dermis, which starts at around 0.5mm below the skin surface. Above that threshold is where results become clinically meaningful. For more aggressive remodelling, such as deep folds or scarring, depths of 0.8mm and above are where the real structural work happens. In the UK, Health Education England recommends that practitioners working up to 0.5mm hold a Level 4 qualification. That is the most common entry point for beauty therapists offering microneedling. A medical practitioner is not bound by those restrictions and can work significantly deeper, guided by anatomy, clinical judgement, and the individual in front of them. To understand why this matters, here is how the main approaches compare in terms of what they stimulate: - **Standard microneedling:** mechanical micro-injury triggers natural platelet activation and growth factor release, initiating collagen production - **RF microneedling:** adds thermal energy to the same mechanism, causing immediate collagen contraction and a stronger remodelling stimulus by amplifying the body's own signalling response through heat - **Microneedling with exosomes:** mechanical stimulus plus a concentrated external signalling input delivered directly into the open channels, working alongside and beyond what the body's own platelets can release Clinical studies comparing microneedling with and without exosomes consistently show superior outcomes across skin texture, elasticity, hydration, and collagen density when exosomes are added. The advantage is well supported in split-face trials and a 2025 systematic review, though the field continues to develop and larger long-term studies are ongoing. ## **My approach at Dr Alluris Aesthetics** I use medical-grade microneedling combined with XO Nature exosomes, a plant-based product derived from Red Root Gromwell stem cells, containing 36 billion exosome particles per vial, rich in growth factors, miRNAs, and peptides. I apply the exosomes during the treatment, using the solution as a medium while needling. Absorption is at its highest while the micro-channels are being actively created, and that is when the exosomes should be going in. I chose a plant-based product deliberately. There are exosome products derived from animal and human cell lines, and I wanted something I was confident in both ethically and clinically. XO Nature is produced using 3D cell culture technology for consistent potency and purity. It does not compromise on results. The depth I work at is a clinical decision for each individual case. Facial skin varies in thickness across different zones and the appropriate depth for the cheek differs from the perioral area or the forehead. That calibration is not a dial turned to maximum. It is a considered choice made for each client, each session, and each area. After treatment I apply a ceramide-based barrier repair cream, which typically reduces redness and sensitivity to under 24 hours, and in some cases considerably less depending on the depth we have worked at. ## **Treatment options that often fit** This combination suits a wide range of skin quality concerns across the face, including texture, dullness, early laxity, and fine lines. I also use it as part of hair restoration programmes on the scalp, where deeper channel formation combined with exosome signalling supports follicle activity in a way that superficial needling cannot replicate. If hair restoration is relevant to you, I have written a detailed article on my three-pillar approach [here](https://www.drallurisaesthetics.co.uk/journal/hair-restoration-programme-three-pillar-approach-scalp). It is also worth knowing that microneedling with exosomes is broadly comparable to polynucleotide treatments in its regenerative aims. The simplest way I can explain the difference: exosomes bring a large number of signalling workers communicating through many different pathways, while polynucleotides work through fewer pathways but with greater intensity per signal. For people who are not suitable for polynucleotide treatments, whether due to a fish or shellfish allergy or a preference to avoid injectables, medical microneedling with exosomes covers similar regenerative ground. I will go into that in more detail in a separate article. ## **What to expect in a consultation with me** I assess the skin before recommending anything. I want to understand what you have tried before, what your skin is actually doing, and whether this is the right programme for you. If it is not, I will say so directly and suggest an alternative. Key things to know: - Sessions typically spaced 3 to 4 weeks apart - Expect up to 24 hours of redness and mild sensitivity after each session, often considerably less - Results build gradually across a course, most visible from session three onwards - Not suitable for active skin conditions, certain medications, or a history of keloid scarring **Where to begin** A consultation is the right starting point. I will assess your skin properly, tell you honestly whether this is the right programme, and outline what a realistic course looks like for you. Book at my Crystal Palace or Mayfair clinic via the website, or message me on WhatsApp: 07721 390017. ## Related Articles Browse more articles and find what’s relevant to you. [![A radiant young woman and a microneedling pen](https://www.drallurisaesthetics.co.uk/hubfs/Imported_Blog_Media/698b080f34f508925c96eb94_Beneath%20the%20Surface%204_12.jpg)](https://www.drallurisaesthetics.co.uk/journal/microneedling-types-explained-london) [Beneath the Surface Series](https://www.drallurisaesthetics.co.uk/journal/tag/beneath-the-surface-series), [Expert Insights](https://www.drallurisaesthetics.co.uk/journal/tag/expert-insights), [Aesthetic Treatments](https://www.drallurisaesthetics.co.uk/journal/tag/aesthetic-treatments) ### [Microneedling Explained: Dermaroller, Dermapen and RF, Which Is Right for You?](https://www.drallurisaesthetics.co.uk/journal/microneedling-types-explained-london) June 12, 2025 Article 4 [Read more](https://www.drallurisaesthetics.co.uk/journal/microneedling-types-explained-london) [![An artistic illustration of a woman in her 40s before and after Fat-Dissolving injections](https://www.drallurisaesthetics.co.uk/hubfs/Imported_Blog_Media/698b080f34f508925c96eb9b_Beneath%20the%20Surface%203_12.jpg)](https://www.drallurisaesthetics.co.uk/journal/fat-dissolving-injections-what-to-expect) [Beneath the Surface Series](https://www.drallurisaesthetics.co.uk/journal/tag/beneath-the-surface-series), [Expert Insights](https://www.drallurisaesthetics.co.uk/journal/tag/expert-insights), [Aesthetic Treatments](https://www.drallurisaesthetics.co.uk/journal/tag/aesthetic-treatments) ### [Fat Dissolving Injections: What to Expect Before, During and After](https://www.drallurisaesthetics.co.uk/journal/fat-dissolving-injections-what-to-expect) June 10, 2025 Article 3 of 12 If you are considering fat dissolving injections for the first time, the most common questions I hear... [Read more](https://www.drallurisaesthetics.co.uk/journal/fat-dissolving-injections-what-to-expect) [![Artistic Illustration of Polynucleotides](https://www.drallurisaesthetics.co.uk/hubfs/Imported_Blog_Media/698b080f34f508925c96eb92_Beneath%20the%20Surface%209_12-1.png)](https://www.drallurisaesthetics.co.uk/journal/polynucleotide-treatment-london) [Beneath the Surface Series](https://www.drallurisaesthetics.co.uk/journal/tag/beneath-the-surface-series), [Expert Insights](https://www.drallurisaesthetics.co.uk/journal/tag/expert-insights), [Aesthetic Treatments](https://www.drallurisaesthetics.co.uk/journal/tag/aesthetic-treatments) ### [Skin & Hair Polynucleotide Treatments](https://www.drallurisaesthetics.co.uk/journal/polynucleotide-treatment-london) July 1, 2025 How DNA Fragments Regenerate Your Skin Article 9 of 12 [Read more](https://www.drallurisaesthetics.co.uk/journal/polynucleotide-treatment-london) [Check all articles](https://www.drallurisaesthetics.co.uk/journal) ### Are you ready to start your Journey with Dr Adam Tap below to book a consultation to discuss your goals, suitability, and a tailored treatment plan with Dr Adam [Book a Consultation](https://partner.pabau.com/online-bookings/dr-alluris-aesthetics-ltd?groupCategory=15721&category=194231&serviceType=0) Subscribe for ### Our Newsletter New articles, clinic insights and offers. 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